Molecular Mechanism Underlying the Renoprotective Action of Vitamin D
نویسندگان
چکیده
منابع مشابه
Molecular mechanism underlying the renoprotective action of vitamin D.
The most well-known function of the vitamin D endocrine system is maintaining calcium and phosphorus homoeostasis, but studies in the past decades have unveiled a wide range of activities for vitamin D that extends beyond the regulation of calcium and phosphorus metabolism. Those activities include regulation of renal and cardiovascular functions and modulation of immune responses through the r...
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1,25-Dihydroxvitamin D3 [1,25(OH)2D3] is the hormonally active form of vitamin D. The genomic mechanism of 1,25(OH)2D3 action involves the direct binding of the 1,25(OH)2D3 activated vitamin D receptor/retinoic X receptor (VDR/RXR) heterodimeric complex to specific DNA sequences. Numerous VDR co-regulatory proteins have been identified, and genome-wide studies have shown that the actions of 1,2...
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ژورنال
عنوان ژورنال: Circulation Journal
سال: 2014
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.cj-14-0058